PRE-CLINICAL SCIENCES
Expertise in the proper care and feeding of your technologies
Pre-Clinical Sciences
The RTI Research team excels at constructing a comprehensive approach tailored to execute on each client's specific study.
-
Protocol development and construction
-
Animal procurement and flexible facility scheduling
-
Biosecure containment with exceptional animal husbandry and clinical care
-
Institutional Animal Care and Use Committee (In-House) and welfare audited
-
Quality Assurance and Control with precise data integrity and full auditing
-
Clear, immediate and expert study communication
-
End of study reporting and scientific/manuscript writing
-
Electronic Data Capture competent
Our combined laboratory and clinical scientists provide a wide spectrum of animal trials including:
- Small molecule, biopharma, and biologics proof of concept and efficacy
- Vaccine and drug safety including full research pathology
- Duration of immunity, immunogenicity, shed/spread
- Pharmacology efficacy and tissue residue
- Feed additive efficacy and performance
For more information please send an email to Sara at info@4rtilab.com
Infectious Disease and Models
RTI's challenge models (and pathogens) are characterized in the literature and well accepted by regulatory authorities world-wide for being the standard by which many vaccines achieve approval and registration. If you dont see your pathogen and model below, good chance we may have some experience with it or can develop for your technology. Models include:
- BOVINE
- Bovine Viral Diarrhea Virus (BVDV), Types 1 & 2
- BVDV/Mannheimia Hemolytica Dual Challenge
- Bovine Respiratory Syncytial Virus (BRSV)
- Bovine Herpes Virus Type 1 (BHV), Infectious Bovine Rhinotracheitis (IBR)
- Bovine Coronavirus
- Bovine Rotavirus
- Leptospirosis
- SWINE
- Porcine Respiratory and Reproductive Syndrome (PRRS)
- Mycoplasma Hyopneumoniae (MHyo)
- Porcine Circovirus Type 2 (PCV)
- Influenza A Virus
- Porcine Epidemic Diarrhea Virus (PEDV)
- E. coli (post-weaning diarrhea)
- Erysipelas
- COMPANION ANIMAL and EQUINE
- Please Inquire
- POULTRY
- Salmonella
- E. coli
- Coccidiosis
- Marek's Disease
- Infectious Bursal Disease
- Bees
- European and North American Foulbrood (Paenibacillus Larvae)
*RTI is very open to shared challenge model development beyond the above mentioned pathogens.
Species, Facilities and Equipment
RTI is a USDA accredited research establishment with the ability to adapt nearly any facility to a sponsor's specific study needs. All facilities are inspected by the authorities and sponsor welfare and QA groups, all are secure, and most are BSL2.
Clinical Research Building (BSL-2)- 10 multipurpose, multi-species (from mice to cattle) rooms individually ventilated equaling 21,000 ft2 of animal space.
- Individual or group housing (bovine, porcine, sheep, goat, companion animal, poultry, lab animals)
- Swine farrowing equipment and nursery pens
- Poultry incubators, hatchers, HEPA isolators and floor pens
- Full necropsy, animal processing/handling, and cooler
- Small scale milking
Hudson Research Building (BSL-2)
- Five multipurpose, multi-species study rooms, individually ventilated (appx 25,000 ft2)
- Full animal handling and housing equipped (cattle, poultry, swine, sheep, goat)
Swine (KA, JR, White, CRB, Hudson)
- Two dedicated farrowing units
- Two grow/finish barns
- Three double L nurseries
Cattle and Equine
- North 40 site (40 acre cattle/horse site)
- Hoop barn (140 x 60ft), cattle feedlots and pens
- More than 100 individual calf huts and large animal handling equipment
Poultry
- Floor Pen, Cage, Biosecure Isolators
- Incubators and Hatchers
- Laying Boxes
Supporting Equipment
- Tractors, feed & mixing wagons, skidsteers, chutes, incineration
- Fleet of 13 biosecure study vehicles
- Animal trailers, panels, penning, scales
Bioanalytical and Research Assays
RTI Research Labs provide expertise, equipment and in-house capability in a broad number of assays and formats including:
- Assay Development and Validation
- Immunofluorescence assays
- Enzyme-linked immunosorbent assay (ELISA)
- Virology
- Virus isolation and identification
- Virus propagation and maintenance
- Microbiology
- Aerobic and anaerobic culturing
- Isolation and identification
- Propagation and maintenance
- Agglutination
- Kirby-Bauer susceptibility
- Minimum inhibitory concentration (MIC) susceptibility testing
- Immunology
- Flow cytometry
- Cytokine analysis
- Lymphocyte proliferation
- Cytotoxicity/ Cell viability
- Molecular Biology
- Hematology
- Complete blood counts (CBC's)
- Slide differentials
- Serology
- Serum neutralization